Sucrose vs Glucose vs Fructose: What’s the Difference?

Sucrose vs Glucose vs Fructose: What’s the Difference?

Written by Melissa Groves on June 8, 2018


If you’re trying to cut back on sugar, you may wonder whether the type of sugar matters.

Sucrose, glucose and fructose are three types of sugar that contain the same number of calories gram for gram.

They’re all found naturally in fruits, vegetables, dairy products and grains but also added to many processed foods.

However, they differ in their chemical structures, the way your body digests and metabolizes them and how they affect your health.

This article examines the main differences between sucrose, glucose and fructose and why they matter.

Sucrose is the scientific name for table sugar.

Sugars are categorized as monosaccharides or disaccharides.

Disaccharides are made up of two, linked monosaccharides and broken back down into the latter during digestion (1Trusted Source).

Sucrose is a disaccharide consisting of one glucose and one fructose molecule, or 50% glucose and 50% fructose.

It’s a naturally occurring carbohydrate found in many fruits, vegetables and grains, but it’s also added to many processed foods, such as candy, ice cream, breakfast cereals, canned foods, soda and other sweetened beverages.

Table sugar and the sucrose found in processed foods are commonly extracted from sugar cane or sugar beets.

Sucrose tastes less sweet than fructose but sweeter than glucose (2Trusted Source).


Glucose is a simple sugar or monosaccharide. It’s your body’s preferred carb-based energy source (1Trusted Source).

Monosaccharides are made up of one single unit of sugar and thus cannot be broken down into simpler compounds.

They’re the building blocks of carbohydrates.

In foods, glucose is most commonly bound to another simple sugar to form either polysaccharide starches or disaccharides, such as sucrose and lactose (1Trusted Source).

It’s often added to processed foods in the form of dextrose, which is extracted from cornstarch.

Glucose is less sweet than fructose and sucrose (2Trusted Source).


Fructose, or “fruit sugar,” is a monosaccharide like glucose (1Trusted Source).

It’s naturally found in fruit, honey, agave and most root vegetables. Moreover, it’s commonly added to processed foods in the form of high-fructose corn syrup.

Fructose is sourced from sugar cane, sugar beets and corn. High-fructose corn syrup is made from cornstarch and contains more fructose than glucose, compared to regular corn syrup (3Trusted Source).

Of the three sugars, fructose has the sweetest taste but least impact on your blood sugar (2Trusted Source).


Sucrose is made up of the simple sugars glucose and fructose. Sucrose, glucose and fructose are found naturally in many foods but also added to processed products.

They’re Digested and Absorbed Differently

Your body digests and absorbs monosaccharides and disaccharides differently.

Since monosaccharides are already in their simplest form, they don’t need to be broken down before your body can use them. They’re absorbed directly into your bloodstream, primarily in your small intestine (4Trusted Source).

On the other hand, disaccharides like sucrose must be broken down into simple sugars before they can be absorbed.

Once the sugars are in their simplest form, they’re metabolized differently.

Glucose Absorption and Use

Glucose is absorbed directly across the lining of the small intestine into your bloodstream, which delivers it to your cells (4Trusted Source5Trusted Source).

It raises blood sugar more quickly than other sugars, which stimulates the release of insulin (6Trusted Source).

Insulin is needed for glucose to enter your cells (7Trusted Source).

Once inside your cells, glucose is either used immediately to create energy or turned into glycogen to be stored in your muscles or liver for future use (8Trusted Source9Trusted Source).

Your body tightly controls your blood sugar levels. When they get too low, glycogen is broken down into glucose and released into your blood to be used for energy (9Trusted Source).

If glucose is unavailable, your liver can make this type of sugar from other fuel sources (9Trusted Source).

Fructose Absorption and Use

Like glucose, fructose is absorbed directly into your bloodstream from the small intestine (4Trusted Source5Trusted Source).

It raises blood sugar levels more gradually than glucose and does not appear to immediately impact insulin levels (6Trusted Source10Trusted Source).

However, even though fructose doesn’t raise your blood sugar right away, it may have more long-term negative effects.

Your liver has to convert fructose into glucose before your body can use it for energy.

Eating large amounts of fructose on a high-calorie diet can raise blood triglyceride levels (11Trusted Source).

Excessive fructose intake may also raise the risk of metabolic syndrome and non-alcoholic fatty liver disease (12Trusted Source).

Sucrose Absorption and Use

Since sucrose is a disaccharide, it must be broken down before your body can use it.

Enzymes in your mouth partially break down sucrose into glucose and fructose. However, the majority of sugar digestion happens in the small intestine (4Trusted Source).

The enzyme sucrase, which is made by the lining of your small intestine, splits sucrose into glucose and fructose. They are then absorbed into your bloodstream as described above (4Trusted Source).

The presence of glucose increases the amount of fructose that is absorbed and also stimulates the release of insulin. This means that more fructose is used to create fat, compared to when this type of sugar is eaten alone (13Trusted Source).

Therefore, eating fructose and glucose together may harm your health more than eating them separately. This may explain why added sugars like high-fructose corn syrup are linked to various health issues.


Glucose and fructose are absorbed directly into your bloodstream, while sucrose must be broken down first. Glucose is used for energy or stored as glycogen. Fructose is converted to glucose or stored as fat.

Fructose May Be the Worst for Health

Your body converts fructose to glucose in the liver to use it for energy. Excess fructose places a burden on your liver, which may lead to a series of metabolic problems (13Trusted Source).

Several studies have demonstrated the harmful effects of high fructose consumption. These include insulin resistance, type 2 diabetes, obesity, fatty liver disease and metabolic syndrome (14Trusted Source15Trusted Source16Trusted Source).

In one 10-week study, people who drank fructose-sweetened beverages had an 8.6% increase in belly fat, compared to 4.8% in those who drank glucose-sweetened drinks (16Trusted Source).

Another study found that while all added sugars can increase your risk of type 2 diabetes and obesity, fructose may be the most harmful (17Trusted Source).

What’s more, fructose has been shown to increase the hunger hormone ghrelin and may make you feel less full after eating (18Trusted Source19Trusted Source).

Since fructose is metabolized in your liver like alcohol, some evidence suggests that it may be similarly addictive. One study found that it activates the reward pathway in your brain, which may lead to increased sugar cravings (2021Trusted Source).


Fructose has been linked to several negative health effects, including obesity, type 2 diabetes, insulin resistance and fatty liver disease. Consuming fructose may also increase feelings of hunger and sugar cravings.

You Should Limit Your Added Sugar Intake

There is no need to avoid sugars that are naturally found in whole foods, such as fruits, vegetables and dairy products. These foods also contain nutrients, fiber and water, which counter any of their negative effects.

The harmful health effects associated with sugar consumption are due to the high amount of added sugar in the typical Western diet.

A survey of over 15,000 Americans found that the average person consumed 82 grams of added sugars per day, or approximately 16% of their total calories — far more than the daily recommendation (22Trusted Source).

The World Health Organization recommends limiting added sugars to 5–10% of your daily calorie consumption. In other words, if you’re eating 2,000 calories per day, keep added sugars to less than 25–50 grams (23).

To put that into perspective, one 12-ounce (355 ml) can of soda contains about 30 grams of added sugar, which is enough to push you over your daily limit (24).

What’s more, sugars are not only added to foods that are obviously sweet like sodas, ice cream and candy, but also to foods you wouldn’t necessarily expect, such as condiments, sauces and frozen foods.

When buying processed foods, always read the ingredient list carefully to look for hidden sugars. Keep in mind that sugar can be listed by over 50 different names.

The most effective way to reduce your sugar intake is to eat mostly whole and unprocessed foods.


Added sugars should be limited, but there is no need to worry about those found naturally in foods. Consuming a diet high in whole foods and low in processed foods is the best way to avoid added sugars.

The Bottom Line

Glucose and fructose are simple sugars or monosaccharides.

Your body can absorb them more easily than the disaccharide sucrose, which must be broken down first.

Fructose may have the most negative health effects, but experts agree that you should limit your intake of added sugar, regardless of the type.

However, there is no need to limit the sugars found naturally in fruits and vegetables.

To ensure a healthy diet, eat whole foods whenever possible and save added sugars for the occasional special treat.

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